Patient-derived models · rare oncology

Predictive preclinical models designed to transform drug development

We build patient-derived experimental models and integrate them with deep clinical, omics and digital-pathology data — so preclinical validation becomes genuinely predictive and clinically relevant.

Phase I to approval
7.9%
Overall probability of approval from Phase I (2011–2020)
Oncology
5.3%
Probability of approval in oncology, a key innovation area
Orphan designation
>50%
Of new drugs approved by CDER in 2023–2024
What we do

Agile, clinically relevant preclinical testing

An integrated patient-derived platform for target identification, compound evaluation and in vitro efficacy — supporting biotech and pharma across early discovery and translational research.

Researcher examining a patient-derived culture

Advanced experimental models

Immortalized patient-derived cell lines today, with a roadmap toward organoids and PDX.
Clinician reviewing integrated patient data

Patient-anchored analysis

Convergence of clinical, omics, bioimaging and digital-pathology data, powered by AI tools.
In vitro drug testing at the bench

Preclinical prediction

In vitro efficacy evaluation, drug repurposing and identification of new therapeutic targets.
The key difference

Our models are anchored in deep patient data

Generalist providers sell standardized models with limited data. We start from real patient samples and keep the clinical context attached.

Generalist providers
  • Standardized models
  • Limited accompanying data
  • Low predictive value
The TheraSigna model
  • Models derived from real patient samples
  • Anonymized clinical data
  • Digital pathology and histopathology
  • Omics data (genomics, transcriptomics)

This integration enables analysis of associations between phenotypes, histological patterns and experimental response — radically increasing predictive value.

Initial traction

Our first agreement validates demand in a highly complex niche

With the INCITE Foundation we are developing preclinical models based on cell lines from liposarcoma patients — a very low-incidence tumor. The collaboration connects us to an international network of institutions and companies dedicated to liposarcoma research.

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INCITE Foundation
Ready to accelerate your research?

Patient-derived liposarcoma models, developed alongside an international research network.